• Design, plan, manage and deliver internal and client research projects

• Perform in vitro experiments and assays to an exceptional standard

• Maintain mammalian cell cultures across a variety of scientific fields and disease settings (e.g. cancer, neuroscience, cardiovascular)

• Develop and optimise cell based assays utilising the automation platform

• Data analysis, interpretation and presentation (including written reports and presentations) of experiment results

• Keeping thorough documentation of work that has been carried out

• Following standard operating procedures where required and establishing new SOPs when required

• Providing feasibility assessments of projects in advance to aid the sales team

• Act as subject matter expert and communicate effectively with clients in scientific meetings

• Keeping up to date with relevant scientific and technical development

• Work well within a team to optimise processes, teach others and learn

• Contribute ideas to technology development strategies and maintain a culture of continual improvement

• Ideally educated to PhD level in cell biology or related fields; equivalent experience in scientific R&D

• 2+ years of postdoctoral or industrial drug discovery experience

• Experience of independent, self-directed work

• Proven ability to disseminate research results e.g. in reports, presentations and peer reviewed journal publications

• Assay development expertise for target ID/validation and/or drug screening, with a good understanding of assay statistics (e.g. Robust Z’, %CV).

• Broad understanding of the drug discovery process

• Experience handling large datasets including data QC and analysis

• Experience of working in an industrial setting

• Broad-based experience in cell biology, ideally including:

• Mammalian cell culture and complex cell models (such as 3D cell models, iPSC or other primary cell systems or co-cultures) including development/optimization of culturing conditions.

• Implementing, performing and troubleshooting a broad range of cell based assays (for example: flow cytometry, imaging microscopy or plate-based assays (such as NanoBRET, HiBiT, ELISA, Luciferase, HTRF and AlphaLISA).

• Practical experience with one or more gene engineering and gene modulation technologies (e.g. CRISPR or RNAi mediated gene modulation)  for cell line engineering/development or genetic perturbation studies.

• Expertise in a wide range of other common cellular and molecular techniques, including qRT-PCR, transfection, SDS-PAGE, Western Blotting,

In addition (desired, but not required): 

• Expertise in neurodegenerative diseases, immunology, oncology and/or immuno-oncology, together with demonstrated experience in complementary advanced techniques including primary cell cultures and 3D cell models

• Proficiency in any advanced cellular and molecular biology techniques (e.g. multiparameter flow cytometry or  high throughput/high content imaging and the associated analysis.

• Experience and knowledge of research processes and activities and requirements to comply with Human Tissue Act

• Experience in the use, programming and troubleshooting of robotic liquid handlers.

• Experience in executing assays using an automated platform

• Experience in programming the Hamilton-Vantage liquid handler using the Instinct V software.

• Experience in programming robotic arms and integrating equipment onto automation platforms.

• Experience in automating complex scientific processes (ideally cell-based assays), including troubleshooting and method validation..

• Basic programming skills, ideally in either Python or C# (not crucial which language - but ability to learn new is very good).

• Experience in setting up and/or running high throughput screening (HTS) assays